St. Martha offers an enriched, challenging curriculum for all students. The core academic program consists of religion, language arts, mathematics, science, and social studies. The curriculum is guided by and adheres to the Archdiocesan of Galveston-Houston Curriculum Guidelines. The curriculum guide for religious instruction is based on Christian values and authentic Catholic doctrine. Curriculum guides for secular subjects incorporate the State of Texas Essential Knowledge and Skills (TEKS), ITBS objectives and the National Standards for Science and Math.

The Catechesis of the Good Shepherd is a Pre-Kindergarten 3 through 3rd grade program of spiritual support for the innate spiritual capacities of children. It conforms carefully to their stages of natural development, to lead them gently to encounter Our Lord Jesus Christ through Scripture, the Liturgy and the Sacraments.